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目的:探讨健脑生智口服液对老年痴呆小鼠的作用。方法:采用颈背部sc 1%D-半乳糖复制小鼠老年痴呆模型,测定其对学习记忆功能、超氧化物歧化酶(SOD)、单胺氧化酶(MAO)、三磷酸腺苷酶(Na+-K+-ATPase)活性的影响。结果:健脑生智口服液高、中、低剂量组能明显增加小鼠学习记忆潜伏时间,减少学习记忆错误次数,提高老年痴呆小鼠SOD,Na+-K+-ATPase活性,降低MAO活性,与模型组比较有显著差异。结论:健脑生智口服液对老年性痴呆有一定的治疗作用。
Objective: To explore the effect of Jiannaoshengzhi oral liquid on mice with senile dementia. Methods: The mouse model of Alzheimer’s disease (AD) was duplicated with sc 1% D-galactose on the back of the neck. The effects on the learning and memory function, activities of superoxide dismutase (SOD), monoamine oxidase (MAO), and ATPase activity of Na + -K + -ATPase Impact. Results: Jiannaoshengzhi Oral Liquid high, medium and low dose groups can significantly increase the learning and memory latency, reduce the number of learning and memory errors, increase SOD, Na + -K + -ATPase activity and reduce MAO activity in mice with Alzheimer’s disease There was significant difference between the model group. Conclusion: Jiannaoshengzhi Oral Liquid has a certain therapeutic effect on senile dementia.