【摘 要】
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Zika virus disease is caused by Zika virus infection,as transmitted by Aedes spp.mosquitoes.Many of the Zika virus strains isolated from patients display different pathogenicities toward humans.The vector mosquitoes for Zika virus are mainly of the Aedes
【机 构】
：
Department of Pathogen Biology,Key Laboratory of Tropical Disease Research of Guangdong Province,Sch
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Zika virus disease is caused by Zika virus infection,as transmitted by Aedes spp.mosquitoes.Many of the Zika virus strains isolated from patients display different pathogenicities toward humans.The vector mosquitoes for Zika virus are mainly of the Aedes genus,especially Aedes aegypti and Aedes albopictus.However,susceptibility and interactions between Aedes spp.mosquitoes and Zika viruses remain unclear.In this study,we chose two Zika virus strains (FSS13025 and PRVABC59) with different abilities to in-fect the primary vector mosquitoes Ae.aegypti and Ae.albopictus.The transcriptomes and small RNA profiles of infected and uninfected mosquitoes were comparatively an-alyzed,and differentially expressed genes were functionally examined using RNA inter-ference.According to the results,the susceptibility of PRVABC59 was higher than that of FSS13025 in Aedes vector mosquitoes,and Ae.aegypti was more susceptible to Zika virus than was Ae.albopictus.For PRVABC59 infection,specific differential expression profiles correlated with Ae.aegypti and Ae.albopictus,and susceptibility was signifi-cantly affected when three targeted genes were successfully knocked down.Compared with PRVABC59,infection of Ae.albopictus with FSS 13025 generated more 21-nt virus small interference RNA.It can be concluded that the susceptibility of vector Aedes spp.mosquitoes to Zika viruses varies and that the interactions between mosquitoes and Zika virus correlate with susceptibility.
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