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结核性脑膜炎(结脑)起病多缓慢,早期症状不典型,常引起误诊,而晚期常因大量浆液性纤维蛋白渗出引起脑脊液(CSF)通路阻塞,导致脑积液,致死、致残率较高。我们从1992年1月至1997年12月用异烟肼(INH)、利福平(RFP)、吡嗪酰胺(PZA)和链霉素(SM)四联抗结核和激素、脱水的基础上,采用CSF置换并鞘内注药的方法治疗CSF蛋白＞1.5g/L的结脑41例,取得良好效果,现报告如下。1 资料与方法1．1 一般资料所有病例均选择为CSF蛋白＞1.5g/L者,男25例,女16例;年龄8个月至14岁11例,14~68岁30例,平均32.4岁。早期(＜7天)5例,中期(8~15天)12例,慢性迁延
Tuberculous meningitis (tuberculous meningitis) more than slow onset, early symptoms are not typical, often leading to misdiagnosis, and often due to a large number of serous fibrin exudation caused by cerebrospinal fluid (CSF) pathway obstruction, resulting in hydrocephalus, death, disability Higher rate. Based on the dehydration of INH, RFP, PZA and streptomycin (SM) quadruple anti-TB and hormones from January 1992 to December 1997, , The use of CSF replacement and intrathecal injection of CSF protein> 1.5g / L of the brain in 41 cases, and achieved good results, are as follows. 1 Materials and Methods 1.1 General Information All cases were selected CSF protein> 1.5g / L, 25 males and 16 females; aged 8 months to 14 years in 11 cases, 14 to 68 years in 30 cases, an average of 32.4 year old. 5 cases were early (<7 days) and 12 cases were metaphase (8 ~ 15 days) with chronic persistent