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目的探讨大肠癌患者血清S100A11和癌胚抗原(carcinoembryonic antigen,CEA)表达水平与肿瘤浸润转移的关系。方法应用ELISA法检测74例大肠癌患者血清S100A11及CEA表达水平,并分析其与临床病理资料的关系,评估单一与联合检测S100A11及CEA在大肠癌肝转移中的诊断价值。结果大肠癌患者血清S100A11、CEA的表达水平在患者性别、年龄、肿瘤大小及大体分型方面差异无统计学意义(P>0.05);在组织学分级、浸润深度、有无淋巴结转移、有无肝转移及Dukes分期方面差异有统计学意义(P<0.05);联合检测血清S100A11及CEA诊断大肠癌肝转移的敏感性为88.5%。结论 S100A11和CEA与大肠癌的浸润转移密切相关;检测血清S100A11及CEA表达水平有助于早期发现大肠癌肝转移。
Objective To investigate the relationship between the expression of serum S100A11 and carcinoembryonic antigen (CEA) and the invasion and metastasis of colorectal cancer. Methods The serum levels of S100A11 and CEA in 74 patients with colorectal cancer were detected by ELISA. The relationship between the expression of S100A11 and CEA was analyzed. The diagnostic value of single and combined detection of S100A11 and CEA in colorectal liver metastasis was evaluated. Results The serum levels of S100A11 and CEA in patients with colorectal cancer had no statistically significant differences in gender, age, tumor size, and gross classification (P>0.05); histological grade, depth of invasion, presence or absence of lymph node metastasis, and The difference in liver metastasis and Dukes staging was statistically significant (P<0.05). The sensitivity of combined detection of serum S100A11 and CEA in the diagnosis of colorectal liver metastases was 88.5%. Conclusions S100A11 and CEA are closely related to the invasion and metastasis of colorectal cancer. Detection of serum S100A11 and CEA levels is helpful for the early detection of liver metastasis of colorectal cancer.