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据美国心脏学会在佛罗里达举行的讨论会上的报告,在有关炎症过程的研究中发现病毒与血管炎有关,并可能与血栓形成有关。费城宾夕法尼亚大学医学院血液学和癌瘤学系内科副教授Douglas B Cines说,他和同事们用人脐带静脉内皮细胞培养来证实1型单纯疱疹病毒的感染能使内皮细胞产生大量的病毒蛋白。当病毒在内皮细胞复制时,病毒蛋白嵌入到内皮细胞表面,与抗体结合和/或补体包被的免疫复合物结合。这种与免疫复合物增强下的结合能吸引被激活的补体蛋白和血循环中的白细胞,然后,这两个系统就能引起炎症。 Cines说,炎症造成免疫学上内皮细胞的损伤,因而可引起血小板的附着。随后,血小板的附着可导致体内某些血管炎症损害的部位生成血栓。
According to a report from the American Heart Association’s Symposium held in Florida, the virus was found to be associated with vasculitis in a study of inflammatory processes that may be associated with thrombosis. Douglas B Cines, an associate professor of medicine at the Department of Hematology and Oncology at the University of Pennsylvania School of Medicine in Philadelphia, said he and his colleagues used human umbilical cord vein endothelial cell cultures to confirm that herpes simplex virus type 1 (HSV-1) can produce large amounts of viral proteins in endothelial cells. As the virus replicates in endothelial cells, the viral protein is embedded on the surface of endothelial cells and binds to antibody-binding and / or complement-coated immune complexes. This increased binding to the immune complex attracts activated complement proteins and circulating white blood cells, which can then cause inflammation. Cines said that inflammation causes immunological damage to endothelial cells, which can cause platelet adhesion. Subsequently, the attachment of platelets can lead to the formation of blood clots in some parts of the body damaged by vascular inflammation.