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红霉素为大环内酯类抗生素,是临床常用的广谱抗生素,其价格低廉,且效果显著,在儿科应用广泛。但是红霉素在用药过程中常常引起胃肠道反应,因而往往遇到患儿及家长拒绝。为减轻或消除这一副作用,临床上常通过减少药物浓度、降低静滴速度、静滴时加入VB6或盐酸山莨菪碱等方法,效果仍不十分理想。为此我们在静滴红霉素前试用消化道粘膜保护剂思密达,患儿胃肠道反应明显减少,在临床上收到满意疗效。现报告如下。
Erythromycin is a macrolide antibiotic. It is a broad-spectrum antibiotic commonly used in clinic. Its price is low and the effect is remarkable. It is widely used in pediatrics. However, erythromycin in the medication process often cause gastrointestinal reactions, which often encounter children and parents refused. In order to reduce or eliminate this side effect, the clinical often by reducing the drug concentration, reduce the infusion rate, intravenous infusion of VB6 or anisodamine hydrochloride and other methods, the effect is still not very satisfactory. For this reason, we try Smectite digestive tract mucosal protective agent before intravenous erythromycin, gastrointestinal reactions in children significantly reduced, clinically received satisfactory results. The report is as follows.