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采用胞质分裂阻滞微核测试法（ＣＢ微核测试法）对７６名丙烯腈（ＡＮ）专业工龄为４～２０年的作业工人外周血双核淋巴细胞微核进行研究。按接触工龄分为５组。结果：外周血双核淋巴细胞微核率随工龄增长而上升，且呈线性正相关（ｒ＝０．９８６５），有显著的统计学意义（Ｐ＜０．０１）。工龄超过２０年的ＡＮ接触工人中，双核细胞微核率与１５～２０年工龄组相近，呈稳定趋势。ＡＮ接触工龄在５年以下，双核细胞微核率上升不明显，接触工龄在５年以上，双核细胞微核明显上升；在接触工龄超过１０年的工人中，双核细胞微核率上升非常明显。ＡＮ接触工龄小于１０年和大于１０年的两组比较，双核细胞微核率有显著差异（Ｐ＜０．０１）
76 micronucleus of peripheral blood mononuclear cells of working workers with working age of 4 to 20 years in acrylonitrile (AN) specialty were studied by cytosolic block micronucleus test (CB micronucleus test). According to the length of service is divided into 5 groups. Results: The frequency of micronuclei in peripheral blood mononuclear lymphocytes increased with the increase of seniority and had a positive linear correlation (r = 0.9865), with significant statistical significance (P <0.01). Among the AN workers exposed to more than 20 years of service, the micronucleus rate of binuclear cells was similar to that of the 15-20 year working age group, showing a steady trend. The contact duration of AN was less than 5 years, and the rate of micronuclei of binuclear cells did not increase obviously. The contact length of service was more than 5 years and the number of micronuclei of binuclear cells increased obviously. The micronucleus rate of binuclear cells increased significantly in workers exposed to more than 10 years of service. There was significant difference (P <0.01) in the rate of micronuclei between the two groups when AN was exposed to less than 10 years and more than 10 years.