论文部分内容阅读
恶性肿瘤的发生与各种基因蛋白共同影响细胞的增殖和分化密切相关。肿瘤抑制基因失活是导致正常上皮恶性变的重要原因。P16和WAF-1均为影响细胞增殖的肿瘤抑制基因[1],其表达的蛋白分别为P16INK4和P21WAF-1。增殖细胞核抗原(proliferatingcell nuclearantigen,PCNA)直接参与细
The occurrence of malignant tumors and a variety of gene proteins affect cell proliferation and differentiation are closely related. Inactivation of tumor suppressor genes is an important cause of malignant transformation of normal epithelium. Both P16 and WAF-1 are tumor suppressor genes that affect cell proliferation [1], and their expressed proteins are P16INK4 and P21WAF-1, respectively. Proliferating cell nuclear antigen (PCNA) directly involved in the fine