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目的探讨尿视黄醇结合蛋白(retinol combined with protein,RBP)、尿N-乙酰-β-D-氨基葡萄糖苷酶(N-acetyl-β-D-glucosaminidase,NAG)、尿半胱氨酸蛋白酶抑制剂C(cystatin C,Cys C)诊断原发性高血压早期肾损害的敏感性及临床意义。方法原发性高血压患者52例(观察组),同期体检健康者30名(对照组),采用ELISA法检测2组尿RBP及尿Cys C水平,采用对硝基苯酚比色法检测2组尿NAG水平,并进行比较分析。结果观察组尿RBP,Cys C,NAG水平均高于对照组(P<0.05);观察组尿NAG,RBP,Cys C阳性率分别为98.1%,96.1%,86.5%;ROC曲线下面积分别为0.952,0.932,0.853;95%CI分别为0.911～0.993,0.875～0.981,0.738～0.926。结论尿NAG,RBP,Cys C有助于高血压肾损害的早期诊断。
Objective To investigate the effects of retinol combined with protein (RBP), urine N-acetyl-β-D-glucosaminidase (NAG), urinary cysteine protease The sensitivity and clinical significance of cystatin C (Cys C) in the diagnosis of early renal damage in patients with essential hypertension. Methods Fifty-two patients with essential hypertension (observation group) and 30 healthy people (control group) were enrolled in this study. Urinary RBP and urinary Cys C levels were measured by ELISA. Urine NAG levels, and comparative analysis. Results The urinary RBP, Cys C and NAG levels in the observation group were significantly higher than those in the control group (P <0.05). The positive rates of urinary NAG, RBP and Cys C in the observation group were 98.1%, 96.1% and 86.5% respectively. The areas under the ROC curve were 0.952,0.932,0.853; 95% CI were 0.911 ~ 0.993,0.875 ~ 0.981,0.738 ~ 0.926. Conclusion Urinary NAG, RBP and Cys C contribute to the early diagnosis of hypertensive renal damage.