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目的：探讨清毒退热煮散剂（QDP）汉疗内毒素发热的疗效及对血浆精氨酸加压素（AVP）、内毒囊（ET）和一氧化氮（NO）水平的影响。方法：165例内毒素发热患者，随机分为给予QDP治疗120例，抗生素45例．疗程均为3d。观察治疗前后AVP、ET和NO水平变化，并与正常对照（30例）比较。结果：经服用QDP后，治疗组总有效率和显效率明显优于抗生素组（P＜0．05）；血浆AVP（7．09±0．5pg/mL）、ET（0．12±0．08EU／ml，）和NO（89．03±14．7μmol／L）含量均比治疗前（AVP10．46±0．80pg/mL，ET0.35±0．05EU/mL和NO124．61±17．19μmol／L）显著下降（P＜0．01）。经抗生素治疗后血浆ET（0．28±0．05EU/mL）含量显著高于服用QDP组（0．12±0．08EU／mL，P＜O．01）。结论：QDP治疗ET性发热，不仅可提高疗效，缩短疗程，而且可显著纠正ET性患者异常的AVP、NO和ET水平；同时表明QDP对内毒素发热具有消炎、杀菌、解热和清除内毒素的功能。
OBJECTIVE: To investigate the therapeutic efficacy of QDR in the treatment of endotoxin fever by Chinese herbal medicine and its effect on plasma arginine vasopressin (AVP), endotoxic vesicle (ET) and nitric oxide (NO) levels. Methods: One hundred and sixty-five endotoxin fever patients were randomly divided into two groups: 120 cases treated with QDP and 45 cases treated with antibiotics. Treatments are all 3d. The changes of AVP, ET and NO levels before and after treatment were observed and compared with the normal controls (30 cases). Results: After taking QDP, the total effective rate and effective rate of the treatment group were significantly better than those of the antibiotic group (P<0.05); plasma AVP (7.09±0.5 pg/mL), ET (0.12±0. The contents of 08EU/ml,) and NO (89.03±14.7μmol/L) were all higher than those before treatment (AVP 10.46±0.80 pg/mL, ET 0.35±0.05 EU/mL and NO 124.61±17. 19μmol/L) decreased significantly (P<0.01). The content of plasma ET (0.28±0.05 EU/mL) after antibiotic treatment was significantly higher than that of the QDP group (0.12±0.08 EU/mL, P<0.01). Conclusion: QDP treatment of ET fever can not only improve the curative effect and shorten the course of treatment, but also can significantly correct the abnormal levels of AVP, NO and ET in patients with ET. It also shows that QDP has anti-inflammatory, bactericidal, antipyretic and endotoxin-eliminating effects on endotoxin fever. The function.