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在一些血液系统恶性肿瘤中,趋化因子受体CXCR4涉及恶性B细胞的迁移和播散。尽管研究发现CXCR4在血液系统肿瘤过表达,但该受体在弥漫大B细胞淋巴瘤(DLBCL)中的作用仍未可知。CXCR4在多种肿瘤中是预后不良的标记,与肿瘤转移及患者生存降低相关。作者研究了CXCR4在体外细胞迁移和体内播散过程中的作用,并进一步分析了94例活检DLBCL患者中CXCR4表达对预后的意义。作者观察到在体外DLBCL细胞系中,CXCR4的表达水平与
In some hematological malignancies, the chemokine receptor CXCR4 is involved in the migration and dissemination of malignant B cells. Although CXCR4 is overexpressed in hematological tumors, the role of this receptor in diffuse large B-cell lymphoma (DLBCL) remains unclear. CXCR4 is a poor prognostic marker in a variety of tumors and is associated with tumor metastasis and reduced patient survival. The authors investigated the role of CXCR4 in cell migration and in vivo dissemination in vitro and further analyzed the significance of CXCR4 expression in prognosis in 94 biopsied DLBCL patients. The authors observed CXCR4 expression levels in vitro in DLBCL cell lines