羟苄四唑头孢菌素是一种杀菌作用较强的新型第二代头孢菌素,兼有第一代和第三代头孢菌素的某些优点。对大多数革兰氏阳性菌和部分阴性菌具有良好的抗菌活性,特别对厌氧梭状芽孢杆菌、流感杆菌、大肠杆菌、肺炎杆菌、部分吲哚阳性变形杆菌、伤寒杆菌、痢疾杆菌等抗菌活性明显优于第一代头孢菌素。但对绿脓杆菌、阴沟杆菌、不动杆菌、肠球菌及脆弱拟杆菌无作用。 国产注射用羟苄四唑头孢菌素,商品名头孢孟多钠于1979年由上海第三制药厂仿制成功,以其甲酯钠(Cefamandole nafate)作为临床制剂。上海第三制药厂抗生素研究所和上海第一医学院华山医院抗菌素临床研究室进行了一系列实验室工作以后,在上海市卫生局主持下,于1983年初由上海第一医学院儿科医院、华山医院、青浦朱家角人民医院、上海市第八、第四、第二人民医院及上 Benzimidazole cephalosporin is a new bactericidal second-generation cephalosporins, both the first-generation and third-generation cephalosporins some of the advantages. For most Gram-positive bacteria and some negative bacteria has good antibacterial activity, especially against Clostridium difficile, influenza bacilli, Escherichia coli, Klebsiella pneumoniae, some Indole positive Proteus, Salmonella typhi, Shigella and other antibacterial Activity was significantly better than the first generation cephalosporins. However, Pseudomonas aeruginosa, cloacae, Acinetobacter, Enterococcus and Bacteroides fragilis no effect. Cefmetazole cephalosporin injection for domestic use, the trade name cefmetaememe sodium was first imitated by Shanghai No.3 Pharmaceutical Factory in 1979, with Cefamandole nafate as its clinical preparation. Shanghai Third Pharmaceutical Factory Antibiotics Institute and Huashan Hospital of Shanghai First Affiliated Hospital of antibiotics clinical laboratory conducted a series of laboratory work under the auspices of the Shanghai Municipal Health Bureau, in 1983 by the Shanghai First Medical College Pediatric Hospital, Huashan Hospital, Qingpu Zhujiajiao People’s Hospital, Shanghai eighth, fourth and second People’s Hospital and