经实验研究证明狂犬病毒街毒株SBD0 7株具有较好的免疫原性后 ,通过RT PCR法 ,克隆了该毒株的糖蛋白 (G)基因 ,并进行了全序列测定。结果表明该株狂犬病毒G基因与疫苗株 (aG株 )的核酸及蛋白同源性分别为 85 8%和 88 5 %。以痘苗病毒为载体成功地表达了该基因 ,经小鼠实验表明能诱生较高滴度的狂犬病毒中和抗体 ,并能保护狂犬病毒致死量的攻击 The experimental study proved that rabies virus street strain SBD0 7 has good immunogenicity, and then cloned the glycoprotein (G) gene of this strain by RT PCR and sequenced. The results showed that the homology between the rabies virus G gene and the vaccine strain (aG strain) was 85.8% and 88.5%, respectively. The vaccinia virus as a vector successfully expressed the gene, the mice experiments showed that rabies virus induced high titer of neutralizing antibodies, and can protect rabies virus lethal dose of attack