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目的研究家兔尿液中氯胺酮及代谢物去甲氯胺酮浓度与血药浓度的动态相关性。方法实验家兔分为氯胺酮灌胃组、静脉注射组和对照组,分别于染毒前和染毒后不同时间点收集尿液和血液。气相色谱/质谱联用(GC/MS)全扫描定性、气相色谱(GC)定量分析血液和尿液样品中氯胺酮及去甲氯胺酮的浓度。采用双变量Pearson相关分析研究尿液中药物浓度和血药浓度的相关性。结果氯胺酮灌胃组和静脉注射组给药后各时间点氯胺酮及去甲氯胺酮在尿液和血液中的浓度相关系数范围在0.11～0.69之间。结论氯胺酮及去甲氯胺酮在尿液和血液中的浓度相关性较差,尿液药物浓度并不能直接反映血药浓度,因此用尿液中氯胺酮浓度推断血药浓度时应慎重考虑。
Objective To study the dynamic correlation between the concentration of ketamine and the concentration of ketamine in urine of rabbits and plasma concentration. Methods Rabbits were divided into ketamine group, intravenous injection group and control group. Urine and blood were collected before and at different time points after exposure. Gas chromatography / mass spectrometry (GC / MS) full scan qualitative, gas chromatography (GC) Quantitative analysis of blood and urine samples ketamine and norethamone concentrations. Bivariate Pearson correlation analysis was used to investigate the correlation between urinary drug concentration and plasma concentration. Results The correlation coefficients of ketamine and norethindrone in urine and blood at different time points after administration of ketamine and intravenous injection group ranged from 0.11 to 0.69. Conclusions The correlation between ketamine and nornicotine in urine and blood is poor. Urine drug concentration does not directly reflect plasma concentration. Therefore, the concentration of ketamine in urine should be considered carefully.