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目的 探讨二联药物方案对早发型重度子痫前期母婴并发症及新生儿Apgar评分的影响,为早发型重度子痫前期的治疗提供依据.方法 选取2014年1月-2017年1月该院收治的早发型重度子痫前期产妇100例,按随机数字表法分为对照组(50例)和观察组(50例),对照组采用低分子肝素钙单用治疗,观察组在此基础上加用丹参注射液辅助治疗.比较两组治疗前后24h尿蛋白量、平均动脉压(MAP)及D-二聚体(D-D)水平,新生儿体质量,1 min Apgar评分,5 min Apgar评分及妊娠结局.结果 观察组产妇治疗后24 h尿蛋白量、MAP及D-D水平均显著优于对照组及治疗前(P＜0.05);观察组产妇新生儿体质量、1 min和5 min Apgar评分均显著低于对照组(P＜0.05);观察组产妇产后出血、胎盘早剥、低蛋白血症及眼底改变发生率均显著低于对照组(P＜0.05);观察组胎儿宫内窘迫及新生儿窒息发生率均显著低于对照组(P＜0.05).结论 二联药物方案用于早发型重度子痫前期产妇可有效提高阴道分娩率,保护心肾功能,下调D-D水平,有助于改善母婴妊娠结局.“,”Objective To explore the effect of bigeminy drug regimen on maternal and neonatal complications and neonatal Apgar score of patientis with early-onset severe preeclampsia,and provide a basis for treatment of early-onset severe preeclampsia.Methods A total of 100 patients with early-onset severe preeclampsia treated in the Fifth Central Hospital of Tianjin from January 2014 to January 2017 were sdeeted and divided into control group and observation group according to random number table,50 patients in each group.The patients in control group were treated by low-molecular heparin calcium,and the patients in observation group were treated by low-molecular heparin calcium and Danshen injection.The levels of 24-hour urinary protein,mean arterial pressure (MAP),D-dimer (D-D),neonatal weights,one-minute and five-minute Apgar scores,and pregnancy outcomes before and after treatment in the two groups were compared.Results The levels of 24-hour urinary protein,MAP,and D-D after treatment in observation group were statistically significantly better than those before treatment and in control group (P＜0.05).Neonatal weight,one-minute and five-minute Apgar scores in observation group were statistically significantly lower than those in control group (P＜0.05).The incidence rates of postpartum hemorrhage,placental abruption,hypoproteinemia,and ocular fundus change in observation group were statistically significantly lower than those in control group (P＜0.05).The incidence rates of fetal intrauterine distress and neonatal asphyxia in observation group were statistically significantly lower than those in control group (P ＜ 0.05)Conclusion Bigeminy drug regimen in treatment of patients with early-onset severe preeclampsia can efficiently increase vaginal delivery rate,protect heart function and kidney function,reduce D-D level,and improve maternal and infant outcomes.