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临床资料患者,女,43岁。主因四肢皮肤发硬、下肢结节8年,伴溃烂、疼痛6个月,于2013年9月就诊。8年前无明显诱因患者双下肢皮肤出现肿胀、渗出,小腿出现2个无痛性结节,在外院诊断为硬皮病,经治疗症状好转。此后结节处经常自行破溃,能挤出白色、质硬物质,用药后创面多能好转;患病期间自觉冬季手脚发凉麻木,手指皮肤变硬且活动受限;间断口服糖皮质激素药物6年余,泼尼松量由30 mg
Clinical data Patients, female, 43 years old. The main cause of limbs and skin hard, lower limb nodules 8 years, with ulceration, pain for 6 months, in September 2013 treatment. 8 years ago, no obvious incentive for patients with lower extremity skin swelling, exudation, calf showed two painless nodules, the diagnosis of scleroderma outside the hospital, the treatment of symptoms improved. Since then nodules often ulcerated on their own, can be extruded white, hard material, the wound can be improved after treatment; during the winter months consciously feel cold and numb hands and feet, finger skin hardening and limited mobility; intermittent oral glucocorticoid drugs For 6 years, the prednisone dose was 30 mg