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目的与方法 :为了给临床提供肿瘤标本细胞的生长信息并筛选敏感性抗癌药 ,提高疗效 ,本文以MTT比色法对 1 0 0例实体瘤原代细胞进行了 8种化疗药物及郑氏植物蛋白对其体外增殖影响作用的测定。结果与结论 :结果表明 8种临床常用的化疗药物中以顺铂、卡铂、5—氟脲嘧啶、丝裂霉素C的抑瘤敏感性较高 ,但不同标本瘤细胞的敏感性药谱不一样 ,提示了肿瘤治疗个体化的必要性。同时显示郑氏植物蛋白对 70 %的标本瘤细胞有促进增殖的作用。长春新碱、阿霉素和足叶乙甙对个别标本瘤细胞也有促增殖作用。
Purpose and Methods: In order to provide clinical information on the growth of tumor specimens and screening for sensitive anticancer drugs to improve efficacy, this article used MTT colorimetry to perform 100 chemotherapeutic agents and 100% chemotherapeutic agents on 100 solid tumor primary cells. Determination of the effect of plant proteins on their proliferation in vitro. RESULTS AND CONCLUSION: The results showed that the anti-tumor sensitivity of cisplatin, carboplatin, 5-fluorouracil, and mitomycin C in 8 clinically common chemotherapy drugs was higher, but the sensitivity spectrum of different tumor cells was different. Not the same, suggesting the need for personalized treatment of cancer. At the same time, Cheng’s plant protein was shown to promote the proliferation of 70% of the specimen tumor cells. Vincristine, doxorubicin, and etoposide also promote proliferation of individual specimens of tumor cells.