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信号转导子与转录激活子(signal transducersand activators of transcription:STAT)是一类生长因子受体和一些非受体类酪氨酸激酶能激活转录因子[1],是Darnell[2]于1990年在研究干扰素(IFN)信号转导通路时首次被发现。STAT蛋白是一类脱氧核糖核酸(DNA)结合蛋白,作为JAK(Janus
Signal transducers and activators of transcription (STAT), a class of growth factor receptors and some non-receptor tyrosine kinases, activate transcription factors [1] and are described by Darnell [2] in 1990 It was first found in the study of the interferon (IFN) signaling pathway. STAT proteins are a class of DNA-binding proteins that act as JAKs (Janus