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目前,角膜病致盲率非常高,而角膜供体严重短缺,所以人工角膜的研究非常有意义。人工角膜是取代混浊角膜组织而用异质成形材料制成的类似人体角膜的一种特殊屈光装置。人工角膜一般包括光学镜柱和周边支架两部分,其中周边支架部分是最为关键的部分。本课题通过利用循环冷冻法和粒子致孔法制备多孔PVA/CF/n-HA复合水凝胶,并针对其作为人工角膜周边支架材料的应用进行了相关性能研究。通过对比其含水率、拉伸强度、X射线衍射图谱、热重分析图,探讨了在聚乙烯醇(PVA)含量固定及制备条件相同时碳纤维(CF)与纳米羟基磷灰石(n-HA)的不同用量对材料性能的影响。结果表明:本材料含水率在68.0%~74.9%,拉伸强度在0.73~1.02MPa。其中,碳纤维含量为60%时,抗拉伸强度为0.98MPa,断裂伸长率为368.3%,含水率为71.1%,材料综合性能较好。本材料孔隙多,利于材料与宿主的生物性愈合,满足支架材料的要求。
Currently, the rate of corneal blindness is very high, while there is a serious shortage of corneal donor, so the study of artificial cornea is very meaningful. Artificial cornea is a special refractive device similar to human cornea made of heterogeneous shaped material instead of cloudy corneal tissue. The artificial cornea generally includes two parts of the optical column and the peripheral support, of which the peripheral support is the most critical part. In this study, the porous PVA / CF / n-HA composite hydrogel was prepared by using the method of freeze-drying and particle perforation, and the related properties were studied for its application as a scaffold for artificial cornea. By comparing the moisture content, tensile strength, X-ray diffraction and thermogravimetric analysis, the effects of carbon fiber (CF) and nano-hydroxyapatite (n-HA ) Different dosage on the material properties. The results show that: the material moisture content of 68.0% to 74.9%, tensile strength at 0.73 ~ 1.02MPa. Among them, when the carbon fiber content is 60%, the tensile strength is 0.98MPa, the elongation at break is 368.3% and the moisture content is 71.1%. The comprehensive properties of the material are good. The porous material, which is conducive to the biological material and host healing, to meet the requirements of scaffolds.