复方中药缓释制剂的研究已引起越来越多的关注,但至今未见有产品上市,其主要原因除体内药动学研究存在很大难度外,如何使处方中各成分在缓释的同时达到同步释放,以期与中医用药的整体观相吻合,亦是研究的难点之一。目前,化学药物口服缓控释固体制剂采用的基本技术是通过控制药物分子在穿过系统和周围介质屏障时的扩 The research of compound traditional Chinese medicine sustained-release preparation has attracted more and more attention, but so far there is no product listed. The main reason is that in addition to the great difficulty in the study of pharmacokinetics in vivo, how to make the ingredients of the prescription slow- To achieve simultaneous release, with the overall view of traditional Chinese medicine medication is also one of the difficulties of the study. At present, the basic technology used in oral controlled release solid preparations of chemical drugs is through the control of drug molecules in the system and the surrounding media through the expansion of the barrier