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目的制备溴吡斯的明磷脂复合物纳米乳(PPNE),并初步对其进行体内外评价。方法采用溶剂挥发法制备溴吡斯的明磷脂复合物,采用伪三元相图法制备磷脂复合物纳米乳,考察其形态、粒径和Zeta电位、体外释放行为以及口服生物利用度。结果制得的磷脂复合物纳米乳在电镜下为类圆形,粒径为26.16 nm,Zeta电位为-3.88 m V,磷脂复合物纳米乳体外释放行为与溴吡斯的明相近,磷脂复合物纳米乳的口服生物利用度为溴吡斯的明的208.1%。结论本实验成功制备了溴吡斯的明磷脂复合物纳米乳,方法简便,具有可重复性,为溴吡斯的明制剂学研究提供了参考。
OBJECTIVE: To prepare the PPNE of triamcinolone dipivoxil and to evaluate it in vitro and in vivo initially. Methods The phospholipid complex of tribromide was prepared by solvent evaporation and the phospholipid nanocomposite was prepared by pseudo-ternary phase diagram. The morphology, particle size and zeta potential, in vitro release behavior and oral bioavailability were studied. Results The obtained phospholipid nanocomposites were round in shape under electron microscopy with a particle size of 26.16 nm and a Zeta potential of -3.88 mV. The release behavior of phospholipid nanoemulsion in vitro was similar to that of pyridostizone. The phospholipid complex The oral bioavailability of nanoemulsion was 208.1% of the brominated benzazepine. Conclusion This experiment successfully prepared the pyridostigmine phospholipid composite nanoemulsion, the method is simple and reproducible, and provides a reference for the study of Mingbusch of Bruoma.