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目的:进一步探讨胃癌的发生、发展与HP持续感染的关系。方法:经胃镜检查观察病变的部位和形态,并在病变部位取3块活组织。对病理诊断为胃癌的235例组织再作必良Gimesa染色,以确立HP感染与否。结果:癌肿病变部位HP感染率在胃窦部占58.33％,胃角部占38.33％,贲门部占37.50％,胃体部占16.95％。在控制不同形态胃癌的影响下,不同部位胃癌间HP感染率有非常显著性差异(P<0.01)。癌肿病变形态HP感染率,在早期隆起型占31.11％,中晚期息内型占75.55％,溃疡型占37.39％,弥漫浸润型占26.67％。在控制不同部位胃癌的影响作用下,不同形态胃癌间的HP感染率,有非常显著性差异(P<0.01)。按组织分型,HP感染率在腺癌中占39.0％,粘液癌占60.0％,两组间比较,有显著性差异(P<0.025)。HP感染阳性胃癌与阴性胃癌患者在年龄、性别两组间比较,无显著性差异(P>0.05)。结论:胃窦部中晚期息肉型癌肿可能与HP持续感染关系最为密切。源于胃组织起源不同,粘液癌HP感染率比腺癌为高。胃癌发生年龄、性别与HP感染无明显相关性。
Objective: To further explore the relationship between the occurrence and development of gastric cancer and HP persistent infection. Methods: The location and morphology of the lesion were observed by gastroscopy, and 3 biopsies were taken in the lesion. The pathological diagnosis of gastric cancer in 235 cases and then make a good Gimesa staining in order to establish the HP infection or not. Results: The prevalence of HP in cancerous lesions was 58.33% in gastric antrum, 38.33% in gastric corner, 37.50% in cardia and 16.95% in gastric body. Under the control of different forms of gastric cancer, there was a significant difference in HP infection rate between different parts of gastric cancer (P <0.01). The prevalence of HP infection in cancer lesions was 31.11% in early stage, 75.55% in late stage, 37.39% in ulcer and 26.67% in diffuse infiltration. There was a significant difference in the HP infection rate between different forms of gastric cancer under the control of gastric cancer in different parts (P <0.01). According to the tissue typing, HP infection rate was 39.0% in adenocarcinoma and 60.0% in mucinous carcinoma, there was a significant difference between the two groups (P <0.025). HP-positive gastric cancer and negative gastric cancer patients in age, gender, no significant difference between the two groups (P> 0.05). Conclusion: Gastric polyps in the advanced gastric cancer may be the most closely related to persistent infection. Originated from the different origins of gastric tissue, mucinous HP infection rate is higher than adenocarcinoma. Gastric cancer age, gender and HP infection no significant correlation.