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目的：探讨肠上皮化生时幽门螺杆菌（hp）感染的情况。方法选择既往内镜诊断肠上皮化生（IM）或萎缩性胃炎内镜复查者共40例，NBI内镜下观察，并取活检，标本行hp免疫组化染色。结果病理诊断为肠化的48块标本中，8块标本有hp感染，hp感染率为16.6%。结论大多数肠化粘膜不存在HP感染。“,”Objective To investigate the relationship between intestinal metaplasia and Hp infection Methods 40 patients suspected lesions associated with IM was further observed by NBI combined with magnifying endoscopy.The biopsy specimens were obtained from regions containing vil ous mucosa for pathological examination,and hp immumohistochemical staining Results 8 of 48 IM pathological y confirmed with hp infection Conclusions: most of intestinal metaplasia without hp infection.