报告4例多发性硬化(MS)患者的发作性瘙痒(PIS),并结合文献病例进行了讨论。PIS是罕见的,但可以是MS的早期和唯一的症状。这种发作是短暂的,通常持续数分钟,为突然发作和迅速中止。每日数次,可被卡马西平控制。捉示PIS可能是由于中枢神经系统中疼痛传导纤维径路上,部分脱髓鞘损害的神经轴索神经元间接触活动的横向扩散所致。 Four episodes of pruritus (PIS) were reported in 4 patients with multiple sclerosis (MS) and were discussed in combination with the literature. PIS is rare, but can be an early and only symptom of MS. The episode is brief and usually lasts for a few minutes for a sudden onset and a quick stop. Several times a day, can be controlled by carbamazepine. PIS may be due to lateral diffusion of contact activity between neuronal axonal neurons that are partially demyelinated on pain-guiding fiber pathways in the central nervous system.