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目的本研究对深圳市龙华区2016年手足口病(Hand-foot-and-mouth disease,HFMD)的流行病学和病原学特征进行分析,为辖区内HFMD预防和控制策略的制订提供重要科学依据。方法从中国疾病预防控制信息系统获取深圳市龙华区2016年HFMD的流行病学数据;采用荧光定量RT-PCR方法对辖区278例HFMD病例样本进行肠道病毒(Enteroviurs,EV)、肠道病毒71型(Enteroviurs 71,EV-A71)和柯萨奇病毒A16(Coxsackievirus A16,CV-A16)核酸检测,并对非EV-A71非CV-A16的其他肠道病毒进行VP1区序列测定进行亚型鉴定和进化分析。结果 2016年深圳市龙华区HFMD发病率较高的两个街道分别是龙华街道和观澜街道;发病曲线呈双峰分布,分别为5—7月份和9—11月份;5岁以下儿童占全部发病数的96.06%;2016年深圳市龙华区HFMD的优势病原为柯萨奇病毒A16(Coxsackievirus A16,CV-A16),构成比为41.53%。结论深圳市龙华区应进一步加强HFMD的流行病学和病原学监测,为进一步完善HFMD防控策略提供科学数据支持。
Objective This study analyzed the epidemiological and etiological characteristics of Hand-foot-and-mouth disease (HFMD) in 2016 in Longhua District of Shenzhen City, and provided an important scientific basis for the formulation of HFMD prevention and control strategies in its jurisdiction . Methods Epidemiological data of HFMD in Longhua District of Shenzhen City were obtained from China CDC Information System in 2016. Enterovirus (Enterovirus) (EV), enterovirus 71 (Enteroviurs 71, EV-A71) and Coxsackievirus A16 (CV-A16) nucleic acids, and the VP1 region sequences of other enterovirus other than EV-A71 non-CV-A16 were tested for subtype identification And evolutionary analysis. Results In 2016, the two streets with a high prevalence of HFMD in Longhua District of Shenzhen were Longhua Street and Guanlan Street respectively. The incidence curves showed bimodal distribution in May-July and September-November respectively. Children under 5 years old accounted for the total incidence (96.06%). In 2016, the predominant pathogen of HFMD in Longhua District of Shenzhen City was Coxsackievirus A16 (CV-A16) with a constituent ratio of 41.53%. Conclusion Longhua District of Shenzhen City should further strengthen the epidemiological and etiological monitoring of HFMD and provide scientific data to further improve the prevention and control strategies of HFMD.