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目的探讨替硝唑辅助治疗慢性盆腔炎的可行性及安全性方法 122例慢性盆腔炎患者,随机分成对照组和治疗组,各61例。所有患者行常规物理治疗,对照组在此基础上采用左旋氧氟沙星静脉滴注治疗,治疗组在对照组基础上采用替硝唑联合左旋氧氟沙星静脉滴注治疗。比较两组患者的治疗效果,观察患者盆腔包块大小以及患者在治疗过程中不良反应的发生情况。结果治疗3个疗程后,治疗组患者总有效率为95.1%,对照组患者总有效率为83.6%,治疗组总有效率显著高于对照组,差异有统计学意义(χ~2=4.2188,P<0.05)。对照组患者不良反应发生率为9.8%,治疗组患者不良反应发生率为6.6%,比较差异无统计学意义(P>0.05),且所有不良反应在治疗结束后自行消失。结论采用替硝唑联合左旋氧氟沙星治疗慢性盆腔炎的疗效较好,能够显著提高治疗总有效率,具有很高的可行性和安全性,值得推广。
Objective To investigate the feasibility and safety of tinidazole in the treatment of chronic pelvic inflammatory disease. 122 patients with chronic pelvic inflammatory disease were randomly divided into control group and treatment group, with 61 cases in each group. All patients underwent routine physical therapy. The control group was treated with intravenous infusion of levofloxacin. The treatment group was treated with intravenous tinidazole and levofloxacin on the basis of the control group. The therapeutic effects of two groups of patients were compared, the size of pelvic mass in patients and the incidence of adverse reactions in the course of treatment were observed. Results After 3 courses of treatment, the total effective rate was 95.1% in the treatment group and 83.6% in the control group. The total effective rate in the treatment group was significantly higher than that in the control group (χ ~ 2 = 4.2188, P <0.05). The incidence of adverse reactions in the control group was 9.8%, and the incidence of adverse reactions in the treatment group was 6.6%, with no significant difference (P> 0.05). All the adverse reactions disappeared on the end of the treatment. Conclusion Tinidazole combined with levofloxacin treatment of chronic pelvic inflammatory disease better curative effect, can significantly improve the total effective rate of treatment, with high feasibility and safety, it is worth promoting.