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光学旋光法是一种无创血糖检测技术,通过测量眼前房水内葡萄糖浓度来确定体内血糖浓度水平。人眼运动引起的实时变化的双折射是实现旋光法无创血糖测量的主要限制因素之一。设计了实时、闭环、双调制多波长偏振系统来测量人工前房内的葡萄糖浓度,人工前房由离体角膜固定在人工眼房上构成。采用眼耦合装置使光直线穿过眼前房从而避免了空气与角膜之间折射率不匹配引起的光线弯曲。存在运动引起的双折射时,采用双波长旋光系统测量眼模型内的葡萄糖浓度,两次预测葡萄糖浓度的标准差分别为18.9mg/dL和15.2mg/dL,表明该系统具有降低活体角膜实变双折射的潜力,有利于实现与血糖浓度相关的眼前房水内葡萄糖浓度的精确测量。
Optical Polarimetry is a noninvasive blood glucose measurement technique that determines the in vivo blood glucose level by measuring the glucose concentration in aqueous humor before the eye. Real-time birefringence caused by the movement of the human eye is one of the major limiting factors in achieving noninvasive blood glucose measurement by the optical rotation method. A real-time, closed-loop, dual-modulation and multi-wavelength polarization system was designed to measure the glucose concentration in artificial anterior chamber. The artificial anterior chamber was composed of cornea fixed in the artificial eye chamber. An eye-coupling device is used to direct light straight through the anterior chamber of the eye to avoid bending of the light caused by mismatch in refractive index between the air and the cornea. In the presence of motion-induced birefringence, the dual-wavelength optical rotation system was used to measure the glucose concentration in the eye model. The standard deviations of the two predicted glucose concentrations were 18.9 mg / dL and 15.2 mg / dL, respectively, indicating that this system has the potential to reduce live corneal solidification The potential for birefringence facilitates the accurate measurement of glucose concentration in the aqueous humor of the anterior chamber of the eye associated with blood glucose levels.