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目的:探讨开腹子宫切除术术式对阴道免疫防御功能的影响,为临床恰当选择经腹子宫切除术术式提供参考。方法:经腹子宫切除术99例分为研究组(37例,次全子宫切除术)和对照组(62例,全子宫切除术),检测其术前及术后1个月阴道分泌物中免疫因子(SIgA、IL-2、-10)含量及病原微生物。结果:两组术后阴道分泌物中免疫因子含量明显下降(P<0.01),对照组下降更明显(P<0.05)。两组术后外阴阴道假丝酵母菌检出率分别为12.1%和39.6%,细菌性阴道病3.0%和18.8%。研究组阴道炎症发生比例明显低于对照组(P<0.05)。结论:经腹全子宫切除术后患者阴道免疫防御功能易受损而发生阴道炎症。
Objective: To investigate the effect of open abdominal hysterectomy on vaginal immune defensive function, to provide a reference for clinical choice of abdominal hysterectomy. Methods: 99 cases of abdominal hysterectomy were divided into study group (37 cases, subtotal hysterectomy) and control group (62 cases, total hysterectomy), and their preoperative and postoperative 1 month vaginal secretions Immune factors (SIgA, IL-2, -10) content and pathogenic microorganisms. Results: The contents of immune factors in vaginal secretions decreased significantly in both groups (P <0.01), but decreased in the control group (P <0.05). The detection rates of vulvovaginal Candida were 12.1% and 39.6% in both groups, 3.0% and 18.8% in bacterial vaginosis. The incidence of vaginal inflammation in the study group was significantly lower than that in the control group (P <0.05). CONCLUSIONS: Vaginal inflammation occurs when the vaginal immune defenses are easily impaired in patients after transabdominal hysterectomy.