关于肝纤维化或肝硬化的诊断,目前以肝活体组织检查或腹腔镜直视下肝活体组织检查最为可靠。但是这些方法,不能多次反复应用,且观察范围也受限制。因此还须用生化方法补充形态学的不足。如丙种球蛋白升高、絮状试验异常、肝循环血量减少等。其中不论那项都只能说明是肝纤维化间接的或是非特异的现象。对于纤维化的程度也不能锐敏而准确地反映出来。最近对与结缔组织增生有关的生化知识大为增加,而且引入临床作为脏器纤维化的诊断指标。有些报告试用胶原蛋白中的特有成分羟 Liver fibrosis or cirrhosis of the diagnosis, the current liver biopsy or laparoscopic liver biopsy under the most reliable. However, these methods can not be repeatedly applied, and the scope of observation is also limited. Therefore, we must use biochemical methods to supplement the lack of morphology. Such as gamma globulin, flocculation test abnormalities, reduced blood circulation, such as liver. No matter what that can only indicate that liver fibrosis is indirect or non-specific phenomenon. The extent of fibrosis can not be reflected sharply and accurately. Recently, biochemical knowledge related to connective tissue hyperplasia has been greatly increased, and it has been introduced into the clinic as a diagnostic indicator of organ fibrosis. Some reports try collagen, a unique ingredient in the hydroxyl