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目的 观察乳腺癌患者服用三苯氧胺 (TAM)后对子宫内膜的影响。方法 2 6例乳腺癌患者服用TAM(TAM组 )后出现阴道异常出血或B超检查发现子宫内膜增厚而行宫腔镜检查及子宫内膜病理检查。另外以同时期无TAM服药史的非乳腺癌患者因绝经后阴道出血而行宫腔镜检查的78例作为对照组。结果 TAM组发生子宫内膜息肉和宫颈息肉共 13例 (5 0 0 % ) ,而对照组为 14例(17 9% ) ,两组比较 ,差异有显著性 (P <0 0 5 )。TAM组发生子宫内膜增生 9例 (34 6 % ) ,明显高于对照组的 12例 (15 4% ,P <0 0 5 )。结论 乳腺癌患者长期服用TAM后子宫内膜病变增多 ,故对这些患者应进行B超监测及宫腔镜检查
Objective To observe the effects of tamoxifen (TAM) on endometrial cancer in breast cancer patients. Methods Twenty-six patients with breast cancer who underwent TAM (TAM group) had abnormal vaginal bleeding or B-ultrasonography and found thickening of the endometrium and hysteroscopy and endometrial pathology. In addition, 78 patients who underwent hysteroscopy for postmenopausal vaginal bleeding in non-breast cancer patients who had no history of TAM administration at the same time served as a control group. Results There were 13 cases (50%) of endometrial polyps and cervical polyps in the TAM group and 14 cases (17%) in the control group. There was a significant difference between the two groups (P < 0.05). In the TAM group, endometrial hyperplasia occurred in 9 cases (34.6%), which was significantly higher than in the control group (12.4%, P < 0.05). Conclusions Patients with breast cancer have increased endometrial lesions after long-term administration of TAM, so B-ultrasound and hysteroscopy should be performed on these patients.