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目的:探讨雄激素在生殖调节中所起的作用。方法:采用2×2析因设计,观察睾酮（T）、孕酮（P）对体外培养的子宫内膜间质细胞生长与分化的调节以及激素问的相互影响。结果:睾酮刺激细胞增殖的同时也促进其分化,使细胞密度增大,漩涡状生长,细胞呈小多角形而产生 PRL。而 P+T促使梭形细胞生长,胞体变粗大,细胞分化成蜕膜细胞,PRL分泌明显增加,但蜕膜细胞很快脱落。结论:睾酮在子宫内膜间质细胞的蜕膜化过程中具有3重作用,它不仅能促进子宫内膜间质细胞分化成多角形细胞,同时还刺激其细胞分裂增生,并调节蜕膜细胞的凋亡。推测雄激素在体内与其它激素间的平衡调节对维持正常子宫内膜的生理功能及妊娠具有重要意义。
Objective: To investigate the role of androgens in reproductive regulation. Methods: 2 × 2 factorial design was used to observe the regulation of testosterone (T) and progesterone (P) on the growth and differentiation of endometrial stromal cells in vitro and the interaction between hormones. RESULTS: Testosterone stimulated cell proliferation while promoting differentiation, resulting in increased cell density, swirling growth and small polygonal cells producing PRL. The P + T promote spindle cell growth, cell body becomes coarse, the cells differentiate into decidual cells, PRL secretion increased significantly, but the decidua cells shed quickly. Conclusion: Testosterone has a 3-fold effect on the process of decidualization of endometrial stromal cells. It not only promotes the differentiation of endometrial stromal cells into polygonal cells, but also stimulates cell division and proliferation and regulates the expression of decidual cells Apoptosis. Speculated that the androgen in the body and other hormones balance between the regulation of the normal endometrium to maintain the physiological function and pregnancy is of great significance.