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目的:研究桂枝加葛根汤(GGT)抗皮肤Ⅰ型变态反应的作用机制。方法:建立Ⅰ型超敏反应实验动物模型。将实验小鼠随机分6组,即空白对照组、扑尔敏组、强的松组及GGT低、中、高剂量组,分别给予GGT 0.50,1.00,1.50 g.kg-1进行动物实验。结果:GGT 3个剂量组能显著地抑制各个稀释度抗血清引起的大鼠背部皮肤蓝色反应斑的直径(P<0.01),其中高、中剂量组疗效与扑尔敏相当。GGT 3个剂量组可抑制组胺及5-羟色胺致小鼠毛细血管通透性增加,对组胺所致小鼠足跖肿胀具有抑制作用(P<0.01),其中高、中剂量组与扑尔敏组的作用无显著差异。结论:GGT可能通过对抗过敏炎性介质的途径发挥抗皮肤Ⅰ型超敏反应的作用。
Objective: To study the mechanism of anti-skin allergic reaction of Gui Zhi plus Pueraria Decoction (GGT). Methods: To establish a type I hypersensitivity experimental animal model. The experimental mice were randomly divided into 6 groups, ie, blank control group, chlorpheniramine group, prednisone group and GGT low, medium and high dose groups and were given GGT 0.50,1.00,1.50 g.kg-1 for animal experiments. Results: The GGT 3 doses significantly inhibited the diameter of the blue reaction spots on the dorsal skin (P <0.01) of each dilution antisera, of which the effect was similar to that of chlorpheniramine in the high and middle dose groups. GGT 3 doses could inhibit the increase of capillary permeability in mice induced by histamine and 5-hydroxytryptamine, and inhibit the swelling of foot in mice induced by histamine (P <0.01) Ermin group no significant difference in the role. Conclusion: GGT may exert its anti-skin type I hypersensitivity effect by antagonizing the allergic inflammatory mediators.