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目的 探讨 2 g/ kg单剂及 0 .4 g/ (kg· d)× 5天静脉免疫球蛋白 (IVIG)两种剂量治疗儿童川崎病(KD)临床疗效。方法 随机选择年龄、性别、发病时间、病情等方面无差异的 KD患儿 35例和 30例 ,分别给予IVIG2 g/ kg单剂静滴和 IVIG0 .4 g/ (kg· d)× 5天静滴 ,其它治疗相同。观察急性期症状缓解时间及冠状动脉损害发生率。结果 KD发病 10天内单剂给予 IVIG2 g/ kg组在退热、粘膜充血消退、手足肿胀消退及皮疹消退时间方面比 IVIG0 .4 g/ (kg· d)× 5天组优越 (P<0 .0 1)。两组冠状动脉损害发生率无显著性差异 (P>0 .0 5 ) ,两组均未见明显不良反应。结论 2 g/ kg IVIG单剂静滴加用大中剂量阿司匹林应当成为 KD首选的初始治疗方案
Objective To investigate the clinical efficacy of two doses of 2 g / kg single dose and 0.4 g / (kg · d) × 5 days intravenous immunoglobulin (IVIG) in children with Kawasaki disease (KD). Methods Thirty-five KD children with no difference in age, sex, onset time and condition were randomly selected and given IVIG2 g / kg single intravenous infusion and IVIG0.4 g / (kg · d) × 5d Drop, the same as other treatments. Observe the acute phase symptom relief time and the incidence of coronary artery lesions. Results Intravenous administration of IVIG2 g / kg within 10 days of onset of KD was superior to IVIG0.4 g / (kg · d) × 5-day group in terms of fever, mucosal hyperemia, subdural swelling of hands and feet and rash subsidence (P <0. 0 1). There was no significant difference in the incidence of coronary artery lesions between the two groups (P> 0.05), with no apparent adverse reactions in both groups. Conclusions Single intravenous infusion of 2 g / kg IVIG plus large-dose aspirin should be the preferred initial treatment for KD