【摘 要】
：
Glucocorticoids are drugs that are controversial in the treat-ment of malignant tumors, especially in regimens using immune checkpoint inhibitors. Some oncologists warn that glucocorticoids might affect or even weaken the therapeu-tic efficacy of PD-1 inh
【机 构】
：
Department of General Surgery,Ruijin Hospital,Shanghai Institute of Digestive Surgery,Shanghai Key L
论文部分内容阅读
Glucocorticoids are drugs that are controversial in the treat-ment of malignant tumors, especially in regimens using immune checkpoint inhibitors. Some oncologists warn that glucocorticoids might affect or even weaken the therapeu-tic efficacy of PD-1 inhibitors. Recently, Xiang et al.1 identi-fied drugs that could target the dual-target of PD-L1/IDO1, and published their finding of “Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downreg-ulation of PD-L1 and IDO1 pathways” in Oncogene, a leading international oncology journal. Clinicians, especially oncolo-gists, are interested in knowing what types of cancers are indi-cators of the drug and what dosage of dexamethasone might be appropriate for assisting cancer immune therapy. Here, the author provides a review of previous reports and their poten-tial value for suggesting treatments involving immune check-points inhibitors.
其他文献
Recently, we have shown that FOXP3, a critical transcription factor in regulatory T cells (Tregs), is expressed in pancreatic epithelial cells, and restrain the activity of CD8+ T cells by upregulating PD-L1, which in turn regulates immune escape in pancr
目的 探讨开腹肝癌切除术与腹腔镜肝癌切除术对肝癌患者免疫应激的影响.方法 选取2018年5月至2020年7月陕西省空军军医大学第二附属医院收治的85例行肝癌切除术的患者,根据手术方式将其分为腹腔镜组(46例)和开腹组(39例).对比两组T淋巴细胞亚群、免疫球蛋白及炎性应激指标水平.结果 治疗前,两组患者T淋巴亚群细胞、免疫球蛋白指标及炎性应激指标比较,差异无统计学意义(P＞0.05).治疗后,两组患者T淋巴亚群细胞CD3+、CD4+及免疫球蛋白(IgA、IgG、IgM)水平均较治疗前降低,CD8+及炎性应
Cancer immunotherapy, especially immune checkpoint blockade therapy (ICB), has revolutionized cancer treatment, providing a potential curable modality for advanced can-cer patients. In immunogenic cancer, such as melanoma and lung cancers with a history o
At the beginning of the last century, Dr. William Coley introduced “Coley\'s toxin” to the scientific community after observing that a small number of patients with sarcoma with infections developed spontaneous tumor regression. “Coley\'s toxin” consi
Circulating tumor cells (CTCs), recognized as intermediaries between primary and distant lesions, are key to understanding the mechanisms of cancer metastasis. Because the dissemina-tion of tumor cells in the circulatory system is a spatially and temporal
目的 探讨腹腔镜与开腹胆囊癌根治术治疗早期胆囊癌的临床研究.方法 回顾性选取2014年1月至2017年7月间空军军医大学第二附属医院收治的行胆囊癌根治术的71例早期胆囊癌患者,根据手术方式不同分为开腹组38例和腹腔镜组33例.腹腔镜组患者行腹腔镜胆囊癌根治术,开腹组患者行开腹胆囊癌根治术,比较两组患者围手术期指标、术后并发症、免疫应激指标、预后无病生存及总生存情况.结果 两组患者术中均顺利完成手术,无围手术期死亡或腹腔镜中转开腹手术病例.腹腔镜组患者手术时间、术中出血量、术后排气时间、胃肠功能恢复时间、下