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目的探讨大剂量吡喹酮治疗华支睾吸虫病临床疗效。方法新鲜粪便30～50g,水洗自然沉淀集卵法镜检华支睾吸虫卵,找到华支睾吸虫卵确诊为华支睾吸虫病。筛选患者住院,用吡喹酮治疗,总剂量:180mg/kg,5日15次,餐后半小时服。奥美拉唑、克拉霉素等药物辅助治疗。结果2265例患者完成全程治疗,治疗期间无严重不良反应,治疗第2d患者精神状态明显改善,食欲增加,第5d右上腹胀痛或不适消除。出院2～3个月后复查粪便1948例,华支睾吸虫卵阴转率100%。结论大剂量吡喹酮治疗华支睾吸虫病,5日15次疗法,效果显著。
Objective To investigate the clinical efficacy of high-dose praziquantel in the treatment of Clonorchiasis sinensis. Methods Fresh excrement 30 ~ 50g, washed naturally precipitated egg method, check Clonorchis sinensis eggs, find Clonorchis sinensis eggs diagnosed as Clonorchiasis. Patients were selected for hospitalization, with praziquantel treatment, the total dose: 180mg / kg, on the 5th 15 times, half an hour after the meal service. Omeprazole, clarithromycin and other drug-assisted treatment. Results Totally 2265 patients completed the whole course of treatment with no serious adverse reactions during the treatment. The mental state of the patients on the 2nd day after treatment was significantly improved, their appetite increased, and the right upper quadrant pain or discomfort was eliminated on the 5th day. 1948 cases of excretion after discharge 2 to 3 months, Clonorchis sinensis egg negative conversion rate of 100%. Conclusion High-dose praziquantel treatment of Clonorchiasis, 15 treatment on the 5th, the effect is significant.