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目的探讨热性惊厥 (febrile convulsion,FC)与细胞因子的关系。方法采用 EL ISA双抗夹心法对 16例热性惊厥患儿和 16例对照组患儿脑脊液中白细胞介素 -6(IL -6)、肿瘤坏死因子α(TNF-α)进行测定比较。结果热性惊厥患儿脑脊液中 IL -6、TNF -α水平明显高于对照组。结论细胞因子参与了热性惊厥的病理过程 ,FC的发病与 IL-6、TNF-α密切相关 ,这些细胞因子的共同作用可导致脑组织功能的异常
Objective To investigate the relationship between febrile convulsion (FC) and cytokines. Methods The levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in cerebrospinal fluid of 16 children with febrile seizures and 16 children of control group were compared by ELISA. Results The levels of IL-6 and TNF-α in cerebrospinal fluid in children with febrile seizures were significantly higher than those in the control group. Conclusions Cytokines are involved in the pathological process of febrile seizures. The pathogenesis of FC is closely related to IL-6 and TNF-α. These cytokines may lead to abnormal brain function