论文部分内容阅读
氯压定因分子量小、具脂溶性、在血浆浓度很低时也有效,故适于经皮给药。经皮氯压定贴膏厚0.2毫米,由四层组成,各层从表面到接触皮肤面依次如下:①,基层:为带色的聚酯薄膜,起物理屏障作用,防止氯压定的丢失②,储药层:含氯压定、矿物油、聚异丁烯和胶体氧化硅,可连续供药一周;③,多微孔丙烯薄膜:控制氯压定从贴膏向皮肤释放的速度;④,山氯压定、矿物油、聚异丁烯和胶体氧化硅组成的粘合剂。每张贴膏含氯压定2.5毫克,制作成七天内以9微克/小时左右的释放速度。使用经皮氯压定后三天左右血浆药物水平即可达到平稳状态;其余4
Clonidine due to small molecular weight, fat-soluble, low plasma concentrations are also effective, it is suitable for transdermal administration. Percutaneous chloride pressure paste plaster thickness 0.2 mm, composed of four layers, each layer from the surface to the skin contact surface were as follows: ①, grassroots: colored polyester film, from the physical barrier to prevent the loss of chlorine pressure set ②, the storage layer: chlorine pressure setting, mineral oil, polyisobutylene and colloidal silicon oxide, a week can be continuous drug supply; ③, microporous propylene film: control chlorine pressure from the paste to the skin release rate; Mountain chlorine pressure Ding, mineral oil, polyisobutylene and colloidal silica adhesive. Each paste containing chlorine pressure set 2.5 mg, made within seven days to 9 micrograms / hour release rate. The use of percutaneous chlorine pressure after about three days to reach a steady state of plasma drug levels; the remaining 4