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目的研究应用曲美他嗪联合阿托伐他汀联合治疗不稳定心绞痛的疗效以及对患者血清中低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)变化水平的影响。方法将2013年5月至2016年5月期间在温县第二人民医院接受治疗的122例不稳定性心绞痛患者作为研究对象,并根据患者入院的先后顺序将其分为对照组与研究组,对照组接受常规治疗,研究组的患者在常规治疗的基础上应用曲美他嗪联合阿托伐他汀联合治疗,对比分析两组患者的临床治疗效果。结果接受治疗后,研究组患者的LDL-C、TG、TC的水平明显低于对照组(P<0.05),研究组患者的临床治疗总有效率为95.1%明显高于对照组的80.3%(P<0.05)差异显著,且有统计学意义。结论应用曲美他嗪联合阿托伐他汀联合治疗不稳定型心绞痛,能够有效改善患者临床指标,提高临床疗效,临床应用价值显著。
Objective To investigate the efficacy of trimetazidine combined with atorvastatin in the treatment of unstable angina pectoris and the changes of serum LDL-C, triglyceride (TG), total cholesterol (TC) influences. Methods A total of 122 patients with unstable angina who were treated in the Second People’s Hospital of Wen County from May 2013 to May 2016 were selected as study subjects and divided into control group and study group according to the sequence of admission, The control group received routine treatment. Patients in the study group were treated with trimetazidine combined with atorvastatin on the basis of routine treatment. The clinical effects of the two groups were compared. Results After treatment, the levels of LDL-C, TG and TC in the study group were significantly lower than those in the control group (P <0.05). The total effective rate of clinical treatment was 95.1% in the study group, which was significantly higher than that in the control group (80.3% P <0.05) significant difference, and have statistical significance. Conclusions The combination of trimetazidine and atorvastatin in the treatment of unstable angina pectoris can effectively improve the clinical indexes and improve the clinical curative effect, and the clinical value is significant.