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目的以聚乙二醇单甲醚-聚乳酸(m PEG-PLA)嵌段共聚物为载体制备蓝萼甲素胶束,并对其进行体外释放研究。方法首先以聚乙二醇单甲醚(m PEG)、D,L-丙交酯(D,L-LA)为原材料,采用熔融开环聚合法合成m PEG-PLA嵌段共聚物,然后采用自乳化-溶剂挥发法制备蓝萼甲素胶束,并研究所制得蓝萼甲素胶束的粒径、载药量、包封率和体外释放行为。结果蓝萼甲素胶束的粒径为21.23~23.01 nm,载药量19.86%~21.32%,包封率77.35%~79.53%。体外释放符合Weibull释药模型:ln[-ln(1-Q)]=0.5652lnt-1.7022(r=0.9672)。结论采用自乳化-溶剂挥发法制备蓝萼甲素胶束的方法简单,重复性好,体外释放表明其具有一定的缓释作用。
OBJECTIVE To prepare the blue callactin micelles using polyethylene glycol monomethyl ether-polylactic acid (m PEG-PLA) block copolymer as carrier, and to study its in vitro release. Methods m PEG-PLA block copolymers were synthesized by melt ring-opening polymerization using polyethylene glycol monomethyl ether (m PEG), D, L-lactide (D, L-LA) Self-emulsifying - solvent evaporation method for the determination of blue callathin micelles, and study prepared blue calmodulin micelles particle size, drug loading, encapsulation efficiency and in vitro release behavior. Results The size of the blue calmodulin micelles was 21.23 ~ 23.01 nm, the drug loading was 19.86% ~ 21.32%, and the entrapment efficiency was 77.35% ~ 79.53%. In vitro release fitted Weibull release model: ln [-ln (1-Q)] = 0.5652lnt-1.7022 (r = 0.9672). Conclusion The method of self-emulsifying-solvent evaporation is simple and reproducible. The release in vitro shows that it has certain sustained release.