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应用光化学的方法建立了颞叶梗塞性学习记忆障碍动物模型。海马区神经介质类氨基酸的变化用微透析技术进行活体动态观测、超微结构改变用ＴＥＭ电镜观察，并同时观察光镜下的神经细胞变化及鼠的学习记忆障碍。结果发现：（１）颞叶梗塞性痴呆鼠其海马区有大量兴奋性和抑制性氨基酸释放；（２）痴呆鼠海马区神经突触有大量囊泡聚集，晚期大小不均；（３）痴呆鼠脑新皮层及海马锥体细胞均有选择性坏死；（４）氨基酸的释放量与选择性神经细胞损伤及学习记忆障碍有关。
The photodynamic method was used to establish an animal model of temporal infarct learning and memory impairment. Changes of neurotransmitter amino acids in hippocampus were observed in vivo using microdialysis technique. The changes of ultrastructure were observed by TEM and the change of neurons in light microscope and the learning and memory impairment in rats were also observed. The results showed that: (1) a large number of excitatory and inhibitory amino acids were released in the hippocampus of temporal lobe dementia rats; (2) there were a large number of synapses in hippocampus of dementia rats, Neonatal rat cortex and hippocampal pyramidal cells were selectively necrosis; (4) The release of amino acids and selective nerve cell injury and learning and memory disorders.