目的探讨环孢素(CsA)对急性脊髓损伤(SCI)大鼠脊髓组织中少突胶质细胞髓鞘糖蛋白(OMgp)表达的影响。方法将SD大鼠分为单纯椎板切除对照组(A组)、急性脊髓损伤组(B组)和急性脊髓损伤后CsA治疗组(C组)，C组在损伤后早期从尾静脉注射CsA治疗。对各组大鼠后肢运动功能行BBB评分评价神经功能状况；分别在术后1、3、7、14d处死各组大鼠，分别取受损节段脊髓行HE染色及免疫组化染色观察形态学变化；应用实时荧光定量PCR技术(RealTime-PCR)方法观察OMgpmRNA的表达。结果 B、C组大鼠在损伤后各个时间点后肢运动功能均有一定程度的恢复；B、C组各个时间点OMgpmRNA表达均显著高于A组(P<0.05)，7d时最高；C组在各个时间点的表达量显著低于B组，差异有统计学意义(P<0.05)。结论大鼠急性脊髓损伤后OMgp显著升高，早期应用CsA对OMgp的表达具有明显的抑制作用。“,”Objective To investigate whether Cyclosporin A(CsA) affect the expression of oligodendrocyte-myelin glycoprotein(OMgp) after acute spinal cord injury in rats. Methods SD rats were divided into three groups: the control group(group A), the spinal cord injury group(group B) and the spinal cord injury with CsA -treated group(group C). The rats of group C were administered CsA through the tail vein at the early stage of spinal cord injury. The movements of hind limbs were observed in all groups and evaluated by BBB score, after that the rats were sacrificed and the injured spinal cord was taken out. The structural change of the rat spinal cord was evaluated by HE staining. The expression of OMgp protein and OMgpmRNA in the rat spinal cord and neighbor areas were detected by immunohistochemistry staining and Real-time Fluorescence Quantitative PCR(RT-PCR), respectively. Results The functional recovery of hind-limb was observed in group B and C at each study time point. After spinal cord injury, the expressions of OMgp at each study time point in group B and C were significantly higher than that of group A(P<0.05), and reach its apex at day 7. Meanwhile, the expression of OMgp at each study time point in group C was significant lower than that of group B(P<0.05). Conclusion The expression of OMgp significantly increased after spinal cord injury, and early CsA administration strongly inhibit the expression of OMgp.