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p27是新近发现的一个广谱CDK抑制剂,主要通过阻断细胞周期中G_1/S期的转换,实现对细胞周期的负调控,进而阻止细胞的增殖和肿瘤的形成,因此,又被认为是一种抑癌基因。本文就近年来对p27的研究作一综述。
P27 is a newly discovered broad-spectrum CDK inhibitor, which is mainly thought to be responsible for the negative regulation of the cell cycle by blocking the G1/S phase transition in the cell cycle, thereby preventing cell proliferation and tumor formation. A tumor suppressor gene. This article reviews the research on p27 in recent years.