目的：观察四君子汤对脾虚患者血清可溶性细胞粘附分子－１（ｓＩＣＡＭ１）和单核细胞功能的影响。方法：采用酶联免疫吸附法和改良噻唑蓝法对６６例脾虚患者血清ｓＩＣＡＭ１和白细胞介素１５（ＩＬ１５）及单核细胞抗体依赖性细胞介导的细胞毒反应（ＡＤＣＣ）进行检测。结果：脾虚患者血清ｓＩＣＡＭ１水平升高，ＩＬ１５分泌减少，ＡＤＣＣ功能下降，表现为免疫功能低下，经过四君子汤治疗后，上述指标恢复正常。结论：四君子汤健脾益气可提高机体免疫功能 Objective: To observe the effect of Sijunzi Decoction on the serum soluble cell adhesion molecule-1 (sICAM-1) and monocyte function in patients with spleen deficiency. METHODS: Serum sICAM1, interleukin15 (IL15) and monocyte-dependent antibody-mediated cytotoxicity (ADCC) in 66 patients with spleen deficiency were detected by enzyme-linked immunosorbent assay and modified thiazolyl blue method. Conduct the test. Results: Serum levels of sICAM-1 in patients with spleen deficiency were elevated, IL-15 secretion was decreased, and ADCC function was decreased. The immune function was low. After treatment with Sijunzi Decoction, the above indicators returned to normal. Conclusion: Sijunzi Decoction can improve the immune function of the body