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目的探讨白藜芦醇(RES)对大鼠阻塞性黄疸疾病治疗作用。方法取大鼠50只,其中10只为假手术组;结扎其他大鼠胆总管建立梗阻性黄疸模型,设为对照组、白藜芦醇高、中、低剂量组(100、50、25mg/kg)。连续灌服药物3周,假手术组和对照组灌服生理盐水,其他组灌服不同剂量的RES。观察肝脏组织形态学改变,检测血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TB)、总胆汁酸(TBA),测量肝组织GSH、SOD、丙二醛(MDA)含量,并做肝组织病理组织学检查。结果对照组血清ALT、AST、TP和TBA水平明显高于假手术组,白藜芦醇组低于对照组。对照组肝组织MDA含量显著升高,SOD含量显著降低(与对照组比较,P<0.05);RES高、中剂量组MDA、GSH水平显著低于对照组(P<0.05),高于假手术组(P<0.05);RES高、中剂量组SOD活力高于对照组(P<0.05);RES低剂量组MDA、GSH含量和SOD活力与对照组比较均无统计学差别。组织学观察表明,RES高、中剂量均能明显减轻肝细胞损伤(P<0.05)。结论 RES可减轻大鼠阻塞性黄疸的发生。
Objective To investigate the therapeutic effect of resveratrol on obstructive jaundice in rats. Methods Fifty rats were obtained, of which 10 were sham-operated group. The obstructive jaundice model was established by ligating the common bile duct of other rats, which was set as the control group. The resveratrol high, middle and low dose groups (100, 50, 25mg / kg). The medicine was administered continuously for 3 weeks. The sham operation group and the control group were given normal saline. The other groups were given different doses of RES. The morphological changes of the liver tissue were observed, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), total bile acid (TBA) SOD, malondialdehyde (MDA) content, and do the liver histopathological examination. Results The levels of serum ALT, AST, TP and TBA in the control group were significantly higher than those in the sham operation group and resveratrol group were lower than those in the control group. The content of MDA in liver tissue of the control group was significantly higher than that of the control group (P <0.05), and the level of MDA was significantly lower than that of the control group (P <0.05) (P <0.05). The activity of SOD in RES high and middle dose groups was higher than that in control group (P <0.05). There was no significant difference in MDA, GSH content and SOD activity between RES low dose group and control group. Histological observation showed that high and medium doses of RES could significantly reduce hepatocellular injury (P <0.05). Conclusion RES can reduce the occurrence of obstructive jaundice in rats.