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目的:观察清金止嗽化痰丸镇咳、祛痰、平喘、抗炎和通便作用,并与原工艺清金止嗽化痰丸比较。方法:用小鼠氨水引咳法、气管酚红法、豚鼠引喘和大鼠气管排痰试验观察该药的镇咳、平喘、祛痰作用;用大鼠足爪抗炎、小鼠碳粒廓清和通便试验观察该药的抗炎和通便作用。结果:清金止嗽化痰丸1.5g/kg能明显延长小鼠咳嗽潜伏期,降低咳嗽次数,促进气管酚红排泌量。该剂量还促进大鼠痰液分泌量,延长豚鼠引喘潜伏期,抑制大鼠足跖肿胀度。3.0g/kg提高小鼠吞噬指数,增加总排便量及实热便秘小鼠干粪点数。6.0g/kg缩短小鼠首次排便时间。结论:清金止嗽化痰丸具有明显镇咳、祛痰、平喘、抗炎和通便作用,该药新工艺与原工艺同等剂量比较上述作用均无显著差别。
Objective: To observe the antitussive, expectorant, antiasthmatic, anti-inflammation and laxative effects of Qingjinzhiehuayu pill, and compare it with the original technology Qingjinzhiyuhuayu pill. METHODS: The antitussive, antiasthmatic, and expectorant effects of the drug were observed with mouse aqueous ammonia induced cough method, tracheal phenol red method, guinea pig induced asthma, and rat tracheal drainage test. Granule clearance and laxative tests were performed to observe the anti-inflammatory and laxative effects of the drug. Results: Qingjin Zhijing Huayu Pills 1.5g/kg can significantly prolong the cough latency of mice, reduce the number of cough, and promote the excretion of phenol red in the trachea. The dose also promoted the secretion of rat sputum, prolonged the guinea pig induced latency period, and inhibited the degree of rat foot swelling. 3.0g/kg increased the phagocytic index of mice, increased the total amount of defecation, and the number of dry feces in mice with constipation. 6.0g/kg shortened the first defecation time in mice. Conclusion: Qingjin Zhijing Huayu Pill has obvious antitussive, expectorant, antiasthmatic, anti-inflammation and laxative effects. There is no significant difference in the above-mentioned effects between the new technology and the original technology.