【摘 要】
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The unique properties of fluorine-containing organic compounds make fluorine substitution attractive for the development of pharmaceuticals and various specialty materials,which have inspired the evolution of diverse C-F bond activation techniques.Althoug
【机 构】
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Leibniz-Institut fur Katalyse e.V. an der Universit?t Rostock,Rostock 18059,Germany;Dalian National
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The unique properties of fluorine-containing organic compounds make fluorine substitution attractive for the development of pharmaceuticals and various specialty materials,which have inspired the evolution of diverse C-F bond activation techniques.Although many advances have been made in functionalizations of activated C-F bonds utilizing transition metal complexes,there are fewer approaches available for nonactivated C-F bonds due to the difficulty in oxidative addition of transition metals to the inert C-F bonds.In this regard,using Lewis acid to abstract the fluoride and light/radical initiator to generate the radical intermediate have emerged as powerful tools for activating those inert C-F bonds.Meanwhile,these transition-metal-free processes are greener,economical,and for the pharmaceutical industry,without heavy metal residues.This review provides an overview of recent C-F bond activations and functionalizations under transition-metal-free conditions.The key mechanisms involved are demonstrated and discussed in detail.Finally,a brief discussion on the existing limitations of this field and our perspective are presented.
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