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动脉粥样斑块破裂、浸润和血小板形成导致不稳定心绞痛和心肌梗死。临床早期诊断困难,常贻误治疗。本实验在犬冠状动脉狭窄和内皮损伤实验模型中,通过识别病变部位激活血小板放射性核素扫描,以明确(99m)~TC标记血小板膜糖蛋白Ⅱb/Ⅲa受体拮抗剂DMP-444的图像特征。对象与方法 20只健康犬,麻醉、开胸插管、监测心电图和动脉血压。经右颈动脉插入7F左冠状动脉导管(Cordis),每隔1～2cm分离左冠状动脉前降支,超声探头持续监测血流。阻塞动脉,致血流下降30％,做冠脉造影明确狭窄。将与9V直流电源连接的0.014英寸钢丝插入狭窄部位,在内皮处用
Atherosclerotic plaque rupture, infiltration and platelet formation lead to unstable angina and myocardial infarction. Early diagnosis of clinical difficulties, often delaying treatment. In this experiment, the platelet radionuclide scanning was activated in the experimental model of canine coronary artery stenosis and endothelial injury to identify the image features of (99m) ~ TC labeled platelet glycoprotein Ⅱb / Ⅲa receptor antagonist DMP-444 . Subjects and Methods Twenty healthy dogs, under anesthesia, thoracotomy, catheterization and arterial blood pressure monitoring. 7F left coronary catheter (Cordis) was inserted through the right carotid artery and the left anterior descending coronary artery was separated every 1 ~ 2cm. The ultrasound probe continuously monitored the blood flow. Block the artery, resulting in blood flow decreased by 30%, make a clear coronary angiography stenosis. Insert a 0.014 inch steel wire, connected to a 9V DC power supply, into a narrow area for use on the inside of the skin