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目的:探讨自身免疫性肝病相关自身抗体谱的检测在PBC诊断中的意义。方法收集我院2011年1月到2013年12月期间的PBC患者32例,对其进行自身免疫性肝病相关自身抗体谱的检测。结果32例PBC患者中,AMA-M2抗体阳性率为56.25%,抗gp210抗体阳性率为37.5%,抗sp100抗体阳性率为18.75%。结论联合检测多种自身抗体对PBC的诊断和鉴别诊断有重要意义。“,”Objective To investigate the clinical significance of the autoantibodies joint detection for the Patients with primary biliary cirrhosis .Methods We col ected a total of 32 patients with primary biliary cirrhosis from January 2011 to December 2013.We detect and analyze the autoantibodies that related with autoimmune liver disease .Results In 32 cases with PBC patients, the AMA - M2 antibody positive rate was 56.25%, the Anti- gp 210 antibody positive rate was 37.5%, the Anti- sp100 antibody positive rate was 18.75%.Conclusion It has important significance that joint detection of a variety of autoantibodies for the diagnosis and differential diagnosis of PBC.