论文部分内容阅读
目的:探讨雌激素受体(ER)、孕激素受体(PR)在卵巢原发性上皮性肿瘤中的临床意义。方法:采用免疫组化法测定67例恶性肿瘤、44例良性肿瘤和10例正常卵巢ER、PR状态。结果:ER、PR阳性率在恶性肿瘤分别为58.2%、26.9%,良性肿瘤分别为36.4%、31.6%,正常卵巢各为40%、70%。恶性肿瘤ER表达明显高于良性肿瘤及正常卵巢(P<0.05),而PR表达则较低(P<0.05)。经多因素生存回归分析,PR有独立预后判断价值。随访资料表明受体均阳性者生存时间明显延长(P<0.05)。结论:卵巢肿瘤中部分存在性激素依赖倾向,受体状态与肿瘤发生、分化及患者预后相关。
Objective: To investigate the clinical significance of estrogen receptor (ER) and progesterone receptor (PR) in ovarian primary epithelial tumors. Methods: Immunohistochemical method was used to determine the status of ER and PR in 67 malignant tumors, 44 benign tumors and 10 normal ovary. Results: The positive rates of ER and PR in malignant tumors were 58.2% and 26.9% respectively. The rates of benign and malignant tumors were 36.4% and 31.6% respectively, and those in normal ovary were 40% and 70% respectively. The expression of ER in malignant tumors was significantly higher than that in benign tumors and normal ovaries (P <0.05), while the expression of PR was lower (P <0.05). By multivariate survival regression analysis, PR has an independent prognostic value. Follow-up data show that the recipients were significantly longer survival time (P <0.05). Conclusion: There is a tendency of sex hormone dependence in ovarian tumors. The status of the receptor is related to tumorigenesis, differentiation and prognosis.