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目的:探讨胃癌CD_(15)表达的意义及其与P-gp表达之间的关系。方法:应用微波-LSAB免疫组织化学法对95例胃癌组织进行CD_(15)和P-gp检测。结果:CD_(15)和P-gp表达阳性率分别为86.3％和70.7％。CD_(15)和P-gp均与肿瘤浸润、转移相关。CD_(15)阳性表达率在胃癌浸润至肌层和浆膜层者明显高于浸润至粘膜层及粘膜下层(P<0.05),伴有淋巴结转移组明显高于无转移组(P<0.05)。P-gp阳性表达率在胃癌浸润至浆膜层者明显高于浸润至肌层和粘膜层及粘膜下层者(P<0.05),伴有淋巴结转移组明显高于无转移组(P<0.05)。CD_(16)表达与P-gp表达有一定关联。结论:CD_(15)与P-gp在胃癌表达具有一致性。
Objective: To investigate the significance of CD_(15) expression in gastric cancer and its relationship with P-gp expression. METHODS: CD_(15) and P-gp were detected in 95 gastric cancer tissues by microwave-LSAB immunohistochemical method. Results: The positive rates of CD_(15) and P-gp expression were 86.3% and 70.7%, respectively. Both CD_(15) and P-gp were associated with tumor invasion and metastasis. The positive rate of CD_(15) was significantly higher in gastric cancer infiltrating into muscular layer and serosal layer than in infiltrating into mucosal layer and submucosa (P<0.05). The lymph node metastasis group was significantly higher than that in non-metastasis group (P<0.05). . The positive rate of P-gp expression was significantly higher in gastric cancer infiltrating into the serosal layer than in the muscular layer and mucosal layer and submucosa (P<0.05). The lymph node metastasis group was significantly higher than that in the non-metastasis group (P<0.05). . The expression of CD_(16) has a certain correlation with P-gp expression. Conclusion: The expression of CD_(15) and P-gp in gastric cancer is consistent.